Metabolic Control Analysis of Complex Biological Systems
نویسندگان
چکیده
A systematic approach is proposed for the metabolic control analysis of various dynamic behaviors in biological systems. The complex kinetic models are reduced by identifying the conservation relations and the time scale analysis. Subsequently, the biological systems are categorized into the three groups: systems with the steady-states, sustained oscillations, or other non-steady states. The sensitivities are measured to calculate the corresponding control coefficients that are defined considering the characteristics of the dynamics of the systems. The proposed approach is illustrated with its application to the dynamic behaviors of a complex biological model.
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تاریخ انتشار 2008